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GZMB / Granzyme B
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
| Gene Name: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2 |
| Target Sequences: | NM_004131 NP_004122.2 P10144 |
Publications (4)
1
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. The Journal of clinical investigation. 2019 February;129:902-914. [Full Text Article]
[PubMed:30667372]
[PMC:PMC6355225]
Related Antibodies: LS-B7602.
2
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Celestine N Wanjalla, Wyatt J McDonnell, Ramesh Ram, Abha Chopra, Rama Gangula, Shay Leary, Mona Mashayekhi, Joshua D Simmons, Christian M Warren, Samuel Bailin, Curtis L Gabriel, Liang Guo, Briana D Furch, Morgan C Lima, Beverly O Woodward, LaToya Hannah, Mark A Pilkinton, Daniela T Fuller, Kenji Kawai, Renu Virmani, Aloke V Finn, Alyssa H Hasty, Simon A Mallal, Spyros A Kalams, John R Koethe. Cell reports. Medicine. 2021 February;2:100205. [Full Text Article]
[PubMed:33665640]
[PMC:PMC7897802]
Related Antibodies: LS-B7602.
3
Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages. Emeric Limagne, Marion Thibaudin, Lisa Nuttin, Aodrenn Spill, Valentin Derangère, Jean-David Fumet, Nadia Amellal, Elisa Peranzoni, Valérie Cattan, François Ghiringhelli. Cancer immunology research. 2019 December;7:1958-1969. [Full Text Article]
[PubMed:31611243]
Related Antibodies: LS-B2783.
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Lysate
(2)
Recombinant
(18)
Target
GZMB / Granzyme B
(20)
Application
SDS-PAGE
(1)
Publications
No
(20)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
GST
(2)
GST, N-terminus
(1)
GST, N-terminus + His, C-terminus
(1)
His
(2)
His, N-Terminal
(2)
His,C-terminus
(2)
His-GST, N-terminus
(1)
Myc-DDK (Flag)
(2)
Species
Human
(14)
Mouse
(5)
Source
293T Cells
(1)
Baculovirus
(1)
E. coli
(6)
HEK 293 Cells
(5)
Human Cells
(1)
Mammalian Cells
(1)
Sf9 Cells
(1)
Wheat Germ Extract
(3)
Yeast
(1)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(7)
Biologically Active
Biologically active
(3)
Baculovirus
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
28.9 kDa
2 µg/$268; 10 µg/$349
E. coli
His, N-Terminal
29.4 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
Wheat Germ Extract
GST
54.1 kDa
2 µg/$439
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27 kDa
50 µg/$854
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human Granzyme B consists of 240 amino acids and has a calculated molecular mass of 27 kDa. As a result of glycosylation, the apparent molecular mass of rhGranzyme B is approximately 36 kDa in SDS-PAGE under reducing conditions.
50 µg/$441
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
10 µg/$344; 50 µg/$584
E. coli
GST, N-terminus + His, C-terminus
51.5 kDa
50 µg/$419
E. coli
His
29.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Wheat Germ Extract
GST
50.6 kDa
2 µg/$439
Yeast
6His, N-terminus
27.5 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
293T Cells
Myc-DDK (Flag)
27.66 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
27.66 kDa
100 µg/$494
E. coli
His-GST, N-terminus
57.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His, N-Terminal
26 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
Sf9 Cells
6His, C-terminus
Biologically active
26.5kDa
5 µg/$301
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
HEK 293 Cells
None
Less than 1 EU/µg (determined by LAL method).
This 244 amino acid recombinant protein has a predicted molecular mass of approximately 27.5 kD. The protein migrates at about 37 kD in DTT-reducing conditions and about 37 kD in non-reducing conditions by SDS-PAGE.The predicted N-terminal amino acid is G
10 µg/$355; 25 µg/$497
HEK 293 Cells
None
Less than 1 EU/µg (determined by LAL method).
This 246 amino acid recombinant protein has a predicted molecular mass of approximately 27.5 kD. The protein migrates at approximately 37 kD in DTT-reducing conditions and approximately 37 kD in non-reducing conditions by SDS-PAGE. The predicted N-termina
10 µg/$355; 25 µg/$497
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