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GZMB / Granzyme B
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
| Gene Name: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2 |
| Target Sequences: | NM_004131 NP_004122.2 P10144 |
Publications (4)
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