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GZMB / Granzyme B
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
| Gene Name: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2 |
| Target Sequences: | NM_004131 NP_004122.2 P10144 |
Publications (4)
1
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. The Journal of clinical investigation. 2019 February;129:902-914. [Full Text Article]
[PubMed:30667372]
[PMC:PMC6355225]
Related Antibodies: LS-B7602.
2
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Celestine N Wanjalla, Wyatt J McDonnell, Ramesh Ram, Abha Chopra, Rama Gangula, Shay Leary, Mona Mashayekhi, Joshua D Simmons, Christian M Warren, Samuel Bailin, Curtis L Gabriel, Liang Guo, Briana D Furch, Morgan C Lima, Beverly O Woodward, LaToya Hannah, Mark A Pilkinton, Daniela T Fuller, Kenji Kawai, Renu Virmani, Aloke V Finn, Alyssa H Hasty, Simon A Mallal, Spyros A Kalams, John R Koethe. Cell reports. Medicine. 2021 February;2:100205. [Full Text Article]
[PubMed:33665640]
[PMC:PMC7897802]
Related Antibodies: LS-B7602.
3
Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages. Emeric Limagne, Marion Thibaudin, Lisa Nuttin, Aodrenn Spill, Valentin Derangère, Jean-David Fumet, Nadia Amellal, Elisa Peranzoni, Valérie Cattan, François Ghiringhelli. Cancer immunology research. 2019 December;7:1958-1969. [Full Text Article]
[PubMed:31611243]
Related Antibodies: LS-B2783.
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Products
ELISA Kits
(27)
Type
Cell-Based
(1)
Custom
(1)
Sandwich
(23)
Sandwich CLIA
(2)
Target
GZMB / Granzyme B
(27)
Reactivity
Human
(9)
Mouse
(9)
Rat
(6)
Chicken
(1)
Monkey
(1)
Porcine
(1)
Rabbit
(1)
Sheep
(1)
Format
12 x 8-Well Microstrips
(3)
96-Well Microplate
(6)
96-Well Strip Plate
(18)
Publications
No
(27)
Sample Type
Adherent Cell Cultures
(1)
Cell Culture Supernatants
(4)
Cell Lysates
(3)
Plasma
(21)
Serum
(21)
Tissue Homogenates
(8)
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$795
Sandwich
96-Well Strip Plate
Monkey
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Chicken
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Sheep
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$669
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,081
Sandwich
96-Well Strip Plate
Human
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$758
Sandwich
96-Well Microplate
Human
2.87 - 700 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
Sandwich
96-Well Strip Plate
Human
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$671
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
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