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GZMA / Granzyme A
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
| Gene Name: | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMA, CTLA3, CTL tryptase, Granzyme-1, H factor, HF, HFSP, Granzyme A, Fragmentin-1, Hanukah factor, Hanukkah factor |
| Target Sequences: | NM_006144 NP_006135.1 P12544 |
Publications (5)
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