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GYPB / CD235b / Glycophorin B
glycophorin B (MNS blood group)
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants.
| Gene Name: | glycophorin B (MNS blood group) |
| Synonyms: | GYPB, Glycophorin-B, GPB, GPB.NY, GYPHe.NY, Glycophorin B (Ss blood group), Glycophorin b precursor, Glycophorin MiIII, HGpMiX, Glycophorin HeP2, Glycophorin MiVI, GpMiIII, HGpMiIII, Sialoglycoprotein delta, SS, PAS-3, SS-active sialoglycoprotein, CD235b, CD235b antigen, Glycophorin MiX, HGpMiVI, MNS, Ss blood group |
| Target Sequences: | NM_002100 NP_002091.3 P06028 |
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