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GUSB / Beta Glucuronidase

glucuronidase, beta

GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.

Gene Name:	glucuronidase, beta
Synonyms:	GUSB, Beta-D-glucuronidase, Beta-G1, Beta-glucuronidase, Beta Glucuronidase, BG, Glucuronidase, beta, MPS7
Target Sequences:	NM_000181

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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