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GTF3A is a zinc finger protein with nine Cis-His zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.
Gene Name: | general transcription factor IIIA |
Synonyms: | GTF3A, AP2, Transcription factor IIIA, TFIIIA |
Target Sequences: | BF242977 AAA75623.1 Q92664 |
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