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GSTA2

glutathione S-transferase alpha 2

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Gene Name: glutathione S-transferase alpha 2
Synonyms: GSTA2, Glutathione S-transferase A2, Gth1, Glutathione s-transferase a1, Glutathione s-transferase a1-1, GST-gamma, Gsta1-1, GTH2, Liver GST2, GST class-alpha member 2, GST HA subunit 2, Gst-epsilon, GST2, GSTA2-2, GTA2, Ha subunit 1
Target Sequences: NM_000846 NP_000837.3 P09210

Publications (2)

1
Glutathione S-transferase A2 promotes hepatocellular carcinoma recurrence after liver transplantation through modulating reactive oxygen species metabolism. Kevin Tak-Pan Ng, Oscar Wai-Ho Yeung, Yin Fan Lam, Jiang Liu, Hui Liu, Li Pang, Xin Xiang Yang, Jiye Zhu, Weiyi Zhang, Matthew Y H Lau, Wen Qi Qiu, Hoi Chung Shiu, Man Kit Lai, Chung Mau Lo, Kwan Man. Cell death discovery. 2021 Jul;7:188. [Full Text Article] [PubMed:34290233] [PMC:PMC8295304] Related Antibodies: LS-C166704.
2
Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells. Meganathan K, Jagtap S, Wagh V, Winkler J, Gaspar JA, Hildebrand D, Trusch M, Lehmann K, Hescheler J, Schlter H, Sachinidis A. PloS one. 2012 7:e44228. [PubMed:22952932] [PMC:PMC3429450] Related Antibodies: LS-C166704.

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GSTA2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
GSTA2 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
GSTA2 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
GSTA2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
GSTA2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GSTA2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).