GSK3B / GSK3 Beta

glycogen synthase kinase 3 beta

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.

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Proteins (16)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (5)

Recombinant (10)

Target

GSK3B / GSK3 Beta (16)

Publications

No (16)

Tag

6His, N-terminus (4)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His,N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (13)

Mouse (1)

Source

293T Cells (2)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (5)

Insect Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (3)

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Human GSK3B / GSK3 Beta Protein (Recombinant His) (Met1-Thr433) - LS-G97523

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.4 kDa

Price:

50 µg/$707

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Human GSK3B / GSK3 Beta Protein (Recombinant 6His, N-terminus) (aa1-420) - LS-G56311

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human GSK3B / GSK3 Beta Protein (Over-Expression Lysate 6His, N-terminus) (Ser2-Thr433) - LS-G26753

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

75 kDa

Price:

100 µg/$298

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GSK3B / GSK3 Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128658

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.6 kDa

Price:

100 µg/$494

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Human GSK3B / GSK3 Beta Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G58771

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse GSK3B / GSK3 Beta Protein (Recombinant His,N-terminus) (Met1-Thr420) - LS-G140020

Source:

Insect Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49 kDa

Price:

50 µg/$707

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GSK3B / GSK3 Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118196

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

100 µg/$494

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Human GSK3B / GSK3 Beta Protein (Recombinant DDK,C-terminus) - LS-G142480

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47.9 kDa

Price:

20 µg/$677

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Human GSK3B / GSK3 Beta Protein (Recombinant GST) (Full Length) - LS-G28734

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.37 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GSK3B / GSK3 Beta Protein (Recombinant His) - LS-G2733

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human GSK3B / GSK3 Beta Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ser2-Thr433) - LS-G26892

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

75 kDa

Price:

200 µl/$283

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Human GSK3B / GSK3 Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76239

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

20 µg/$150

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Human GSK3B / GSK3 Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76240

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.6 kDa

Price:

20 µg/$150

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Human GSK3B / GSK3 Beta Protein (Recombinant 6His, N-terminus) (aa1-420) - LS-G57182

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human GSK3B / GSK3 Beta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65766

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

20 µg/$1,107

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Human GSK3B / GSK3 Beta Protein (Recombinant His) (aa1-300) - LS-G140981

Source:

E. coli

Sequence Length:

299 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

33 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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