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Growth Hormone Receptor / GHR

growth hormone receptor

Growth Hormone Receptor / GHR is a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: growth hormone receptor
Synonyms: GHR, Growth hormone receptor, GH receptor, Growth hormone binding protein, Serum binding protein, GHBP
Target Sequences: NM_000163 NP_000154.1 P10912

Publications (1)

1
Growth hormone is permissive for neoplastic colon growth. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:E3250-9. (WB; Human) [Full Text Article] [PubMed:27226307] [PMC:PMC4988562]

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (2)
Recombinant (14)
Growth Hormone Receptor / GHR (16)
No (16)
6His, C-terminus (3)
6His-SUMO, N-terminus (1)
Fc (1)
Fc, C-terminus (2)
GST, N-terminus (1)
His (1)
His,C-terminus (1)
His-Fc (1)
His-T7 (3)
Myc-DDK (Flag) (2)
Human (5)
Macaque (1)
Mouse (5)
Pig (1)
Rat (3)
293F Cells (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Human Cells (4)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (6)
Growth Hormone Receptor / GHR Protein - Eukaryotic Growth Hormone By SDS-PAGE
Select
293F Cells
6His, C-terminus
23.6kDa
50 µg/$632; 10 µg/$311; 200 µg/$1,200; 100 µg/$1,008; 1 mg/$2,430; 500 µg/$1,934; 5 mg/$4,411; 2 mg/$2,623
Growth Hormone Receptor / GHR Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Growth Hormone Receptor / GHR Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Growth Hormone Receptor / GHR Protein - Recombinant Growth Hormone Receptor By SDS-PAGE
Select
E. coli
His-T7
32.5 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
Growth Hormone Receptor / GHR Protein - Recombinant Growth Hormone Receptor By SDS-PAGE
Select
E. coli
His-T7
30.7 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
Growth Hormone Receptor / GHR Protein - Recombinant Growth Hormone Receptor By SDS-PAGE
Select
E. coli
His-T7
29.1 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.3kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.3 kDa
10 µg/$266; 50 µg/$339
Growth Hormone Receptor / GHR Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, C-terminus
30.2 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Growth Hormone Receptor / GHR Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, C-terminus
30.3 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.3 kDa
100 µg/$843
Growth Hormone Receptor / GHR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
71.5 kDa
100 µg/$710
Growth Hormone Receptor / GHR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
71.5 kDa
20 µg/$215
Select
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
56.8 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
55.4 kDa
100 µg/$721
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
29.6 kDa
100 µg/$721
Viewing 1-16 of 16 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).