Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

GRN / Granulin

granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene Name: granulin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: GRN, Acrogranin, CLN11, Epithelin precursor, GEP, gp88, Granulin, Granulin-epithelin, Granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin
Target Sequences: NM_002087 NP_002078.1 P28799

Publications (1)

1
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Holler CJ, Taylor G, Deng Q, Kukar T. eNeuro. 2017 August;4: [Full Text Article] [PubMed:28828399] [PMC:PMC5562298] Related Antibodies: LS-C154960.

Viewing 1-25 of 98 items
GRN / Granulin Antibody - Anti-GRN / Granulin antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human GRN / Granulin
Human
IHC, IHC-P, IP, WB
Unconjugated
50µg   0.25mg/ml   $485.00
GRN / Granulin Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human GRN / Granulin
Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
GRN / Granulin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Guinea pig Polyclonal to Human GRN / Granulin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
GRN / Granulin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human GRN / Granulin
Human
IHC, IHC-P, WB
Unconjugated
50µl   0.5mg/ml   $425.00
GRN / Granulin Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human GRN / Granulin
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
GRN / Granulin Antibody - GRN antibody (1 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
Goat Polyclonal to Human GRN / Granulin
Mouse, Rat, Hamster, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
Select
Mouse Monoclonal (IgG2a) to Human GRN / Granulin
Human
ELISA, IP, WB
Unconjugated
100µg   $695.00
GRN / Granulin Antibody - GRN antibody (1 ug/ml) staining of HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
Goat Polyclonal to Human GRN / Granulin
Human
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
GRN / Granulin Antibody - Immunofluorescence of monoclonal antibody to GRN on HeLa cell. [antibody concentration 10 ug/ml]
Select
Mouse Monoclonal [clone 1F5] (IgG2a,k) to Human GRN / Granulin
Human
ELISA, IF, WB
Unconjugated
100µg   $365.00
Select
Rat Monoclonal (IgG2a) to Mouse GRN / Granulin
Mouse
ELISA
Unconjugated
500µg   $815.00
Select
Rabbit Monoclonal [clone 019] (IgG) to Mouse GRN / Granulin
Mouse
ELISA
Unconjugated, Preservative Free
50µl   $245.00; 100µl   $305.00; 1ml   $1,335.00
GRN / Granulin Antibody - Western blot of recombinant GRN / Progranulin / Granulin.
Select
Rabbit Polyclonal to Mouse GRN / Granulin
Mouse
WB
Unconjugated
100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $545.00
GRN / Granulin Antibody - 1:100 staining human kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human GRN / Granulin
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
GRN / Granulin Antibody - IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI1F9] (IgG1) to Human GRN / Granulin
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI1F9] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
GRN / Granulin Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2F4] (IgG1) to Human GRN / Granulin
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI2F4] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human GRN / Granulin
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $335.00
Select
Mouse Monoclonal to Human GRN / Granulin
Human
ELISA, ICC, IF
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00; 1ml   $995.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI4B9] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI4B9] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI3H6] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI3H6] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
Mouse Monoclonal [clone OTI2D1] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
GRN / Granulin Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
Mouse Monoclonal [clone OTI2D1] (IgG1) to Human GRN / Granulin
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00

Viewing 1-25 of 98 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).