GRK6

G protein-coupled receptor kinase 6

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

GRK6 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His,N-terminus + GST (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human GRK6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65673

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.8 kDa

Price:

20 µg/$1,107

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Human GRK6 Protein (Recombinant GST, N-terminus) (aa71-170) - LS-G58737

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GRK6 Protein (Recombinant His-T7) (aa186-448) - LS-G24677

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.7 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human GRK6 Protein (Recombinant GST) (Full Length) - LS-G28704

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

93.7 kDa

Price:

2 µg/$439

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Human GRK6 Protein (Recombinant His,N-terminus + GST) (Met1-Arg589) - LS-G139995

Source:

Insect Cells

Tag:

His,N-terminus + GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

95.1 kDa

Price:

50 µg/$707

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GRK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122546

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.8 kDa

Price:

100 µg/$494

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Human GRK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76005

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.8 kDa

Price:

20 µg/$150

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Human GRK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76006

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.24 kDa

Price:

20 µg/$215

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GRK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118204

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.24 kDa

Price:

100 µg/$710

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