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GRK4

G protein-coupled receptor kinase 4

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Gene Name:	G protein-coupled receptor kinase 4
Family/Subfamily:	Protein Kinase , GPRK
Synonyms:	GRK4, GPRK4, GPRK2L, GRK4a, IT11, ITI1
Target Sequences:	NM_182982 NP_892027.2 P32298

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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