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GRIN2C / NMDAR2C / NR2C

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

GRIN2C / NMDAR2C / NR2C is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants.

Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Family/Subfamily: Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)
Synonyms: GRIN2C, GluN2C, NMDA receptor 2C, NMDAR2C, NR2C, GluR epsilon 3
Target Sequences: NM_000835 NP_000826.2 Q14957

Publications (2)

1
Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses. Ruel J, Chabbert C, Nouvian R, Bendris R, Eybalin M, Leger CL, Bourien J, Mersel M, Puel JL. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:7313-23. [PubMed:18632935]
2
Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. Allen MA, Andrysik Z, Dengler VL, Mellert HS, Guarnieri A, Freeman JA, Sullivan KD, Galbraith MD, Luo X, Kraus WL, Dowell RD, Espinosa JM. eLife. 2014 3:e02200. (WB; Human) [PubMed:24867637] [PMC:PMC4033189] Related Antibodies: LS-C157785.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
GRIN2C / NMDAR2C / NR2C (3)
No (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
GRIN2C / NMDAR2C / NR2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
134.21 kDa
20 µg/$215
GRIN2C / NMDAR2C / NR2C Protein - 12.5% SDS-PAGE of human GRIN2C stained with Coomassie Blue
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Wheat Germ Extract
GST
44 kDa
10 µg/$479; 25 µg/$670
GRIN2C / NMDAR2C / NR2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
134.21 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).