Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
|Gene Name:||glutamate receptor, ionotropic, AMPA 3|
|Family/Subfamily:||Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)|
|Synonyms:||GRIA3, AMPA 3, Glutamate receptor 3, Glutamate receptor C, GLUR-C, GLUR3, GLURC, Glutamate receptor subunit 3, DJ1171F9.1, GluA3, GluR-3, GLUR-K3, MRX94|
|Target Sequences:||NM_000828 NP_000819.3 P42263|
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