Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
|Gene Name:||glutamate receptor, ionotropic, AMPA 3|
|Family/Subfamily:||Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)|
|Synonyms:||GRIA3, AMPA 3, Glutamate receptor 3, Glutamate receptor C, GLUR-C, GLUR3, GLURC, Glutamate receptor subunit 3, DJ1171F9.1, GluA3, GluR-3, GLUR-K3, MRX94|
|Target Sequences:||NM_000828 NP_000819.3 P42263|
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