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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GRIA2 / GLUR2

glutamate receptor, ionotropic, AMPA 2

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Gene Name: glutamate receptor, ionotropic, AMPA 2
Family/Subfamily: Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)
Synonyms: GRIA2, AMPA 2, GluR-K2, Glutamate receptor 2, HBGR2, GluA2, GluR-2, GluR-B, GLUR2, GLURB
Target Sequences: NM_000826 NP_000817.2 P42262

Filtered by: None
Type
Over-Expression Lysate (5)
Synthetic Peptide (1)
Target
GRIA2 / GLUR2 (6)
Tag
Myc + DDK (5)
Species
Human (3)
Source
293T Cells (2)
HEK 293 Cells (3)
Synthetic (1)
Purification
Purified (1)
Showing 1-6 of 6 results

GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G119829
HEK 293 Cells
Myc + DDK
93.6 kDa
100µg  $475.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G119828
HEK 293 Cells
Myc + DDK
98.85 kDa
100µg  $475.00

GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G122975
HEK 293 Cells
Myc + DDK
98.91 kDa
100µg  $475.00

Human GRIA2 / GLUR2 Protein (Synthetic Peptide) - LS-G37580
Synthetic
None
50µg  $245.00

Human GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G76172
293T Cells
Myc + DDK
98.91 kDa
20µg  $195.00

Human GRIA2 / GLUR2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G76173
293T Cells
Myc + DDK
93.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-6 of 6 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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