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GRIA1 / GLUR1
glutamate receptor, ionotropic, AMPA 1
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
| Gene Name: | glutamate receptor, ionotropic, AMPA 1 |
| Family/Subfamily: | Ion channel , Glutamate receptor - ionotropic (NMDA receptor) |
| Synonyms: | GRIA1, AMPA 1, GluR-K1, HBGR1, GLUH1, GLUR1, GLURA, Glutamate receptor 1, GluR-A, GluA1, GluR-1 |
| Target Sequences: | NM_000827 NP_000818.2 P42261 |
Publications (1)
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