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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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GRAP
GRB2-related adaptor protein
GRAP is a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
| Gene Name: | GRB2-related adaptor protein |
| Synonyms: | GRAP, GRB2-related adaptor protein, GRB2-related adapter protein |
| Target Sequences: | NM_006613 NP_006604.1 Q13588 |
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