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GPT / Alanine Transaminase is cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
Gene Name: | glutamic-pyruvate transaminase (alanine aminotransferase) |
Synonyms: | GPT, AAT1, ALT1, Alanine aminotransferase, Alanine aminotransferase 1, GPT 1, GPT1 |
Target Sequences: | NM_005309 NP_005300.1 P24298 |
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