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GPSM2 / LGN
G-protein signaling modulator 2
GPSM2 / LGN belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).
| Gene Name: | G-protein signaling modulator 2 |
| Synonyms: | GPSM2, DFNB82, LGN, PINS, CMCS, Mosaic protein LGN |
| Target Sequences: | NM_013296 NP_037428.3 P81274 |
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