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GPR75

G protein-coupled receptor 75

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Name: G protein-coupled receptor 75
Family/Subfamily: GPCR , Orphan-A
Synonyms: GPR75, G protein-coupled receptor 75, GPR-chr2, WI31133, GPRchr2, WI-31133
Target Sequences: NM_006794 NP_006785.1 O95800

Publications (1)

1
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease. Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M Coolen, Fan Fan, Richard J Roman. Frontiers in neurology. 2020 October;11:983. [Full Text Article] [PubMed:33013649] [PMC:PMC7499024] Related Antibodies: LS-A1589, LS-A1594.

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Proteins (3)
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GPR75 (3)
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6His, N-terminus (1)
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GPR75 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
GPR75 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.2 kDa
20 µg/$150
GPR75 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.2 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).