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GPR68 / OGR1

G protein-coupled receptor 68

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

Gene Name:	G protein-coupled receptor 68
Family/Subfamily:	GPCR , Lysophospholipid/Lysosphingolipid
Synonyms:	GPR68, Brgrb, G protein-coupled receptor 68, G-protein coupled receptor 68, OGR1, Brgr1, GPR12A, OGR-1
Target Sequences:	NM_003485 NP_003476.3 Q15743

Publications (4)

Proton-sensing G-protein-coupled receptors. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Nature. 2003 425:93-8. (IHC; Rat) [PubMed:12955148] Related Antibodies: LS-A1194.

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:2643-8. (Rat) [PubMed:15695591] [PMC:PMC548977] Related Antibodies: LS-A1194.

Expression of and role for ovarian cancer G-protein coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A and Odgren PR. The Journal of biological chemistry. 2006 281:23598-605. (ICC; Rat) [PubMed:16787916] Related Antibodies: LS-A1194.

Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. Parry DA, Smith CE, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC, Simmer JP, Ahmed M, Jafri H, Johnson CA, Inglehearn CF, Mighell AJ. American journal of human genetics. 2016 October;99:984-990. (Human) [Full Text Article] [PubMed:27693231] [PMC:PMC5065684] Related Antibodies: LS-A1194.

Mouse/Human GPR68 / OGR1 (Cell-Based ELISA) ELISA Kit - LS-F3213

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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