GPR48 / LGR4

leucine-rich repeat containing G protein-coupled receptor 4

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

GPR48 / LGR4 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human GPR48 / LGR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88155

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.3 kDa

Price:

20 µg/$215

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GPR48 / LGR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111695

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.3 kDa

Price:

100 µg/$710

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Human GPR48 / LGR4 Protein (Recombinant GST, N-terminus) (aa852-950) - LS-G62695

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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