GPR3 has been identified as a constitutively active lysophospholipid/lysosphingolipid receptor. GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle where GPR3 maintains meiotic arrest in mouse oocytes. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype Mice deficient in GPR3 exhibit premature ovarian failure due to early oocyte aging (Ledent et al. 2005).
|Gene Name:||G protein-coupled receptor 3|
|Family/Subfamily:||GPCR , Lysophospholipid/Lysosphingolipid|
|Synonyms:||GPR3, ACCA, ACCA orphan receptor, G protein-coupled receptor 3, GPCR3, Hacca, G-protein coupled receptor 3|
|Target Sequences:||NM_005281 NP_005272.1 P46089|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.