GPR182 / ADMR

G protein-coupled receptor 182

G Protein-Coupled Receptor L1/G10D (GPR182) has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) ( McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

GPR182 / ADMR (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human GPR182 / ADMR Protein (Recombinant GST, N-terminus) (aa1-54) - LS-G61825

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GPR182 / ADMR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88105

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

20 µg/$150

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GPR182 / ADMR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101005

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

100 µg/$494

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