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GPR182 / ADMR
G protein-coupled receptor 182
G Protein-Coupled Receptor L1/G10D (GPR182) has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) ( McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor.
| Gene Name: | G protein-coupled receptor 182 |
| Family/Subfamily: | GPCR , Orphan-A |
| Synonyms: | GPR182, 7TMR, Adrenomedullin L1 receptor, AM-R, AMR, ADMR, Adrenomedullin receptor, G protein-coupled receptor 182, HrhAMR, G-protein coupled receptor 182, Gamrh, HAMR, RAMR, G10D |
| Target Sequences: | NM_007264 NP_009195.1 O15218 |
Publications (1)
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