Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
G Protein-Coupled Receptor L1/G10D (GPR182) has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) ( McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor.
|Gene Name:||G protein-coupled receptor 182|
|Family/Subfamily:||GPCR , Orphan-A|
|Synonyms:||GPR182, 7TMR, Adrenomedullin L1 receptor, AM-R, AMR, ADMR, Adrenomedullin receptor, G protein-coupled receptor 182, HrhAMR, G-protein coupled receptor 182, Gamrh, HAMR, RAMR, G10D|
|Target Sequences:||NM_007264 NP_009195.1 O15218|
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