GPR161

G protein-coupled receptor 161

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

GPR161 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human GPR161 Protein (Recombinant GST, N-terminus) (aa362-460) - LS-G61997

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GPR161 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83782

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59 kDa

Price:

20 µg/$150

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Human GPR161 Protein (Recombinant GST) (Full Length) - LS-G22236

Source:

E. coli

Tag:

GST

Molecular Weight:

30.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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GPR161 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102406

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59 kDa

Price:

100 µg/$494

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