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GPNMB / Osteoactivin

glycoprotein (transmembrane) nmb

GPNMB / Osteoactivin is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: glycoprotein (transmembrane) nmb
Synonyms: GPNMB, Glycoprotein nmb-like protein, HGFIN, Glycoprotein NMB, Osteoactivin, Transmembrane glycoprotein NMB
Target Sequences: NM_002510 NP_002501.1 Q14956

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Products
Antibodies (57)
Primary (57)
GPNMB / Osteoactivin (57)
Human (54)
Mouse (16)
Rat (10)
Bat (4)
Bovine (7)
Chimpanzee (6)
Dog (10)
Gibbon (9)
Guinea pig (4)
Hamster (8)
Horse (8)
Monkey (3)
Pig (3)
Rabbit (8)
Zebrafish (4)
IHC (16)
IHC-P (10)
WB (48)
ELISA (25)
ICC (1)
IF (2)
rabbit (30)
mouse (27)
Product Group
IHCPlus (2)
IgG (23)
IgG1 (15)
IgG1,k (7)
IgG2a (4)
IgG2a,k (1)
monoclonal mc (27)
polyclonal pc (30)
1A8 (1)
3A5 (1)
7C10E5 (1)
OTI1E3 (2)
OTI1G10 (2)
OTI2A10 (2)
OTI2E10 (2)
OTI2F9 (2)
OTI2H7 (2)
OTI5C2 (2)
OTI7E3 (2)
OTI8A10 (2)
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (9)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (36)
aa541-569 (8)
aa50-99 (4)
aa74-123 (4)
aa143-192 (3)
aa1-502 (2)
aa508-572 (2)
aa104-203 (1)
aa31-260 (1)
aa551-568 (1)
No (56)
Yes (1)
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa50-99) Antibody
Rabbit, Mouse, Bovine, Hamster, Horse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa50-99) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Hamster, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$459
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa50-99) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Hamster, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa50-99) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Hamster, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$459
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (3A5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$495
GPNMB / Osteoactivin Antibody - IHC of paraffin-embedded breast cancer tissues using GPNMB mouse monoclonal antibody with DAB staining.
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (aa31-260) (7C10E5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$415
GPNMB / Osteoactivin Antibody - IHC of paraffin-embedded Human lymphoma tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (OTI8A10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
GPNMB / Osteoactivin Antibody - Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (Carrier-free) (OTI8A10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
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GPNMB / Osteoactivin Rabbit anti-Mouse Polyclonal (aa1-502) Antibody
Mouse
ELISA
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
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GPNMB / Osteoactivin Rabbit anti-Mouse Polyclonal (aa1-502) Antibody
Mouse
ELISA
Unconjugated
100 µl/$275; 200 µl/$312; 400 µl/$350
GPNMB / Osteoactivin Antibody - 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa74-123) Antibody
Zebrafish, Horse, Bat, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Human
WB
Unconjugated
100 µl/$434
GPNMB / Osteoactivin Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPNMB (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPNMB (1:2000).
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (OTI1E3) Antibody
Human
WB
Unconjugated
100 µl/$409
GPNMB / Osteoactivin Antibody - Western blot analysis of extracts of various cell lines, using GPNMB antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
GPNMB / Osteoactivin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (OTI2A10) Antibody
Human
IHC, WB
Unconjugated
100 µl/$409
GPNMB / Osteoactivin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (Carrier-free) (OTI2A10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$411
GPNMB / Osteoactivin Antibody - Western blot analysis of extracts of A375 cells using GPNMB antibody. The lane on the left was treated with blocking peptide.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
GPNMB / Osteoactivin Antibody - Immunofluorescence staining of GPNMB in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human GPNMB polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
GPNMB / Osteoactivin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (OTI2F9) Antibody
Human
IHC
Unconjugated
100 µl/$409
GPNMB / Osteoactivin Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (Carrier-free) (OTI2F9) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$473
Select
GPNMB / Osteoactivin Mouse anti-Human Monoclonal (aa104-203) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$582
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GPNMB / Osteoactivin Mouse anti-Human Monoclonal (PE) (1A8) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$734
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GPNMB / Osteoactivin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$347
Select
GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa541-569) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$614
GPNMB / Osteoactivin Antibody - Anti-GPNMB antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GPNMB / Osteoactivin Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Mouse, Dog, Bovine, Rat, Pig, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).