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GPIHBP1

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

GPIHBP1 is a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants.

Gene Name:	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Synonyms:	GPIHBP1, GPI-HBP1, LOC338328
Target Sequences:	NM_178172 NP_835466.2 Q8IV16

Publications (4)

Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. Journal of lipid research. 2008 49:1312-21. (IHC) [PubMed:18340083] [PMC:PMC3055742]

The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. The Journal of biological chemistry. 2008 283:29554-62. [PubMed:18713736] [PMC:PMC2662032]

The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. Molecular endocrinology (Baltimore, Md.). 2008 22:2496-504. [PubMed:18787041] [PMC:PMC2582544]

Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. The Journal of biological chemistry. 2009 284:30240-7. [PubMed:19726683] [PMC:PMC2781579]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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