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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
GPD1 encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | glycerol-3-phosphate dehydrogenase 1 (soluble) |
| Synonyms: | GPD1, Glycerophosphate dehydrogenase, GPDH-C, HTGTI, GPD-C |
| Target Sequences: | NM_005276 NP_005267.2 P21695 |
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