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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
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GPC3 / Glypican 3
glypican 3
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
| Gene Name: | glypican 3 |
| Synonyms: | GPC3, DGSX, Glypican proteoglycan 3, Glypican 3, Glypican-3, GTR2-2, Intestinal protein OCI-5, SGB, SGBS1, SGBS, MXR7, OCI-5, OCI5, SDYS, Secreted glypican-3, Heparan sulphate proteoglycan |
| Target Sequences: | NM_004484 NP_004475.1 P51654 |
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