GP1BB / CD42c

glycoprotein Ib (platelet), beta polypeptide

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.

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Products

Proteins (5)

Type

Recombinant (5)

Target

GP1BB / CD42c (5)

Publications

No (5)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

Fc (1)

His (1)

His-T7 (2)

Species

Human (2)

Mouse (1)

Rat (2)

Source

E. coli (3)

Human Cells (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human GP1BB / CD42c Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (Full Length) - LS-G136909

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Molecular Weight:

39.3 kDa

Price:

100 µg/$1,801; 20 µg/$1,247

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Mouse GP1BB / CD42c Protein (Recombinant His-T7) (aa53-176) - LS-G24183

Source:

E. coli

Tag:

His-T7

Molecular Weight:

17.2 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Rat GP1BB / CD42c Protein (Recombinant Fc) (Met1-Cys147) - LS-G98403

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.1 kDa

Price:

100 µg/$843

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Human GP1BB / CD42c Protein (Recombinant His) (Met1-Cys147) - LS-G97518

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.3 kDa

Price:

100 µg/$843

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Rat GP1BB / CD42c Protein (Recombinant His-T7) (aa52-164) - LS-G13207

Source:

E. coli

Tag:

His-T7

Molecular Weight:

16.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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