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GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
| Gene Name: | guanine nucleotide binding protein-like 3 (nucleolar)-like |
| Synonyms: | GNL3L, Novel GTPase, RP11-353K22.1 |
| Target Sequences: | NM_019067 NP_061940.1 Q9NVN8 |
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