Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
206-374-1102
Fax:
206-577-4565
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

GNAS

GNAS complex locus

The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase (Hayward et al., 1998). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Gene Name: GNAS complex locus
Synonyms: GNAS, AHO, C20orf45, Extra large alphas protein, GSP, GNAS complex locus, GNASXL, NESP, PHP1B, PHP1C, PHP1A, POH, SCG6, XLalphas, GNAS1, GPSA, GSA, NESP55, Protein ALEX, Secretogranin VI
Target Sequences: NM_080425 NP_536350.2 Q5JWF2

☰ Filters
Antibodies (89)
Proteins (16)
ELISA Kits (6)
Custom (2)
Over-Expression Lysate (10)
Primary (89)
Recombinant (6)
Sandwich (3)
Sandwich CLIA (1)
GNAS (111)
Human (92)
Mouse (22)
Rat (16)
Bat (10)
Bovine (11)
Chicken (1)
Chimpanzee (6)
Dog (12)
Drosophila (1)
Gibbon (9)
Guinea pig (9)
Hamster (7)
Horse (11)
Insect (1)
Monkey (12)
Pig (16)
Primate (1)
Rabbit (8)
Xenopus (1)
Zebrafish (5)
IHC (29)
IHC-P (8)
WB (79)
Flo (10)
ELISA (36)
ICC (7)
IF (10)
IP (3)
Peptide-ELISA (2)
rabbit (70)
mouse (18)
goat (1)
Product Group
IHCPlus (3)
IgG (61)
IgG1 (7)
IgG2a (6)
IgG2b (4)
IgM (1)
monoclonal mc (18)
polyclonal pc (71)
2A2B7 (1)
7G6G5 (1)
OTI12D9 (2)
OTI13D7 (2)
OTI13G5 (2)
OTI7A4 (2)
OTI7A6 (2)
OTI7D7 (2)
OTI7H4 (2)
12 x 8-Well Microstrips (1)
96-Well Strip Plate (5)
AP Conjugated (4)
APC Conjugated (4)
Azide-free (3)
Biotin Conjugated (11)
Carrier-free (7)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (4)
Preservative Free (4)
Unconjugated (48)
aa287-315 (9)
aa217-244 (8)
aa640-667 (8)
aa121-170 (4)
aa297-346 (4)
aa51-100 (4)
aa1028-1037 (1)
aa36-85 (1)
aa385-394 (1)
aa51-83 (1)
aa721-734 (1)
No (111)
Plasma (3)
Serum (3)
Tissue Homogenates (1)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
Myc-DDK (Flag) (13)
Human (11)
293T Cells (5)
E. coli (2)
HEK 293 Cells (8)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
GNAS Antibody - Anti-GNAS antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
GNAS Rabbit anti-Human Polyclonal (aa36-85) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GNAS Antibody - Anti-GNAS antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
GNAS Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
GNAS Antibody - Anti-GNAS antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Select
GNAS Rabbit anti-Human Polyclonal (aa385-394) Antibody
Human, Primate
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
GNAS Antibody - GNAS Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
GNAS Antibody - GNAS antibody ARP42694_T100-NP_536351-GNAS(GNAS complex locus) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GNAS Rabbit anti-Human Polyclonal (aa51-100) Antibody
Mouse, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$387
Select
GNAS Rabbit anti-Bovine Polyclonal (aa1028-1037) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Pig, Horse, Bat, Bovine, Mouse, Dog, Rat, Hamster, Human, Monkey
ICC, IP, WB
Unconjugated
50 µl/$579
GNAS Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GNAS Rabbit anti-Human Polyclonal (aa297-346) Antibody
Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human, Monkey
WB
Unconjugated
100 µl/$387
GNAS Antibody - All lanes: Anti-GNAS Antibody (N-Term) at 1:8000 dilution. Lane 1: HepG2 whole cell lysate. Lane 2: Raji whole cell lysate. Lane 3: mouse brain lysate. Lane 4: rat brain lysate. Lane 5: human cerebellum lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 46 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Select
GNAS Rabbit anti-Human Polyclonal (aa51-83) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
200 µl/$381
GNAS Antibody - GNAS antibody (1 ug/ml) staining of Jurkat lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
GNAS Goat anti-Human Polyclonal (aa721-734) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$455
GNAS Antibody - Jurkat cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GNAS Rabbit anti-Human Polyclonal (aa121-170) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µl/$387
GNAS Antibody - Western blot analysis of extracts of various cell lines, using GNAS antibody.
Select
GNAS Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Select
GNAS Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
GNAS Antibody - GNAS Antibody(Ascites)western blot of mouse brain tissue lysates (35 ug/lane). The GNAS antibody detected the GNAS protein (arrow).
Select
GNAS Mouse anti-Human Monoclonal (aa287-315) Antibody
Mouse, Human
WB
Unconjugated
0.1 ml/$381
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) Antibody
Human
Flo, IF, IHC, WB
Unconjugated
200 µl/$642
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal (aa287-315) (AP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200 µl/$825
Select
GNAS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$321
GNAS Antibody - IHC image of GNAS Antibody diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
GNAS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$284; 100 µg/$348
GNAS Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-GNAS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GNAS Mouse anti-Human Monoclonal (OTI7A4) Antibody
Human
IHC, WB
Unconjugated
100 µl/$409
GNAS Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-GNAS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
Select
GNAS Mouse anti-Human Monoclonal (OTI13G5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$409
GNAS Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GNAS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GNAS Mouse anti-Human Monoclonal (Carrier-free) (OTI7A6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
Viewing 1-25 of 111 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).