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GMPS / GMP Synthase
guanine monphosphate synthase
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
| Gene Name: | guanine monphosphate synthase |
| Synonyms: | GMPS, GMP synthetase, Glutamine amidotransferase, GMP synthase, MLL/GMPS fusion protein |
| Target Sequences: | NM_003875 NP_003866.1 P49915 |
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