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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GLUD1/Glutamate Dehydrogenase

glutamate dehydrogenase 1

GLUD1/Glutamate Dehydrogenase is glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.

Gene Name: glutamate dehydrogenase 1
Synonyms: GLUD1, GDH1, GDH 1, Glutamate dehydrogenase 1, Glutamate dehydrogenase 2, GDH, GLUD
Target Sequences: NM_005271 NP_005262.1 P00367

Publications (1)

1
Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. Bao X, Pal R, Hascup KN, Wang Y, Wang WT, Xu W, Hui D, Agbas A, Wang X, Michaelis ML, Choi IY, Belousov AB, Gerhardt GA, Michaelis EK. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:13929-44. [PubMed:19890003] [PMC:PMC2811066]


GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $2,755.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
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Goat Polyclonal to Human GLUD1/Glutamate Dehydrogenase
Mouse, Pig, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Chicken, Zebrafish, Pig, Horse, Bovine, Rabbit, Mouse, Rat, Human, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Chicken, Zebrafish, Pig, Horse, Bovine, Rabbit, Mouse, Rat, Human, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-GLUD1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Chicken, Zebrafish, Pig, Horse, Bovine, Rabbit, Mouse, Rat, Human, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
GLUD1/Glutamate Dehydrogenase Antibody - Immunohistochemical analysis of GLUD1 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human GLUD1/Glutamate Dehydrogenase
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $255.00; 100µl   1mg/ml   $295.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IF, IHC, WB
Unconjugated
10mg   $295.00
Select
Rabbit Polyclonal to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IF, IHC, WB
Unconjugated
1mg   $485.00
Select
Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IF, IHC, WB
Biotin Conjugated
1ml   $405.00
GLUD1/Glutamate Dehydrogenase Antibody - Immunohistochemistry of paraffin-embedded human colon tissue.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
GLUD1/Glutamate Dehydrogenase Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
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Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, ID, IE, Inhb, WB
Unconjugated
5mg   $465.00
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Mouse Monoclonal (IgG1) to Clostridium difficile GLUD1/Glutamate Dehydrogenase
Clostridium difficile
ELISA, IF, LateralFlow
Unconjugated
1mg   $385.00
Select
Mouse Monoclonal (IgG2b) to Clostridium difficile GLUD1/Glutamate Dehydrogenase
Clostridium difficile
ELISA, IF, LateralFlow
Unconjugated
1mg   $385.00
Select
Mouse Monoclonal (IgG2b) to Clostridium difficile GLUD1/Glutamate Dehydrogenase
Clostridium difficile
ELISA, IF, LateralFlow
Unconjugated
1mg   $385.00
Select
Rabbit Polyclonal (IgG) to Human GLUD1/Glutamate Dehydrogenase
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IHC, WB
HRP Conjugated
100µg   $740.00
GLUD1/Glutamate Dehydrogenase Antibody - Dot Blot results of Rabbit Anti-Glutamate Dehydrogenase Biotin Conjugated. Antigen: Glutamate Dehydrogenase. Blot loaded at 3 fold dilution: 1. 100ng, 2. 33.3ng, 3. 11.1ng, 4. 3.70ng, 5. 1.23ng.Primary Antibody: Rabbit Anti-Glutamate Dehydrogenase Biotin 1µg/mL for 1hr at RT. Secondary Antibody: Streptavidin-HRP (Sat 1:40,000 for 30min at RT. Imaging System ChemiDoc, Filter used: Chemi.
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Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
DB, ELISA, IP, WB
Biotin Conjugated, Lyophilized
100µg   1mg/ml   $425.00
GLUD1/Glutamate Dehydrogenase Antibody - Dot Blot results of rabbit Anti-Glutamate Dehydrogenase Biotin Conjugated. Antigen: Glutamate Dehydrogenase. Blot loaded at 3 fold dilution: 1. 100ng, 2. 33.3ng, 3. 11.1ng, 4. 3.70ng, 5. 1.23ng. Blocking: MB-070 Buffer for 30 minutes at RT. Primary Antibody: Rabbit Anti-Glutamate Dehydrogenase Biotin 1µg/mL for 1hr at RT. Secondary Antibody: Streptavidin-HRP (S000-03) at 1:40,000 for 30min at RT. Imaging System ChemiDoc, Filter used: Chemi.
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Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
DB, ELISA, IP, WB
Biotin Conjugated, Liquid
25µl   1mg/ml   $235.00
Select
Rabbit Polyclonal to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IP, WB
Unconjugated
10ml   $225.00
Select
Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IP, WB
Unconjugated, Lyophilized
100µg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IP, WB
Unconjugated, Liquid
25µl   1mg/ml   $235.00
GLUD1/Glutamate Dehydrogenase Antibody - Anti-Bovine Glutamate Dehydrogenase Antibody - Western Blot. Western blot analysis is shown using anti-bovine glutamate dehydrogenase antibody to detect the enzyme from bovine liver preparations. Comparison to a molecular weight marker indicates a predominant band of ~62 kD. The higher molecular weight band may represent a subunit dimer. A 4-20% gradient gel was used to separate proteins prior to transfer to 0.2 micron nitrocellulose. The blot was incubated with a 1:1000 dilution of the antibody for 2 h at room temperature followed by detection using IRDye800 labeled Goat-a-Rabbit IgG [H&L] ( diluted 1:5000 for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.
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Rabbit Polyclonal to Bovine GLUD1/Glutamate Dehydrogenase
Bovine
ELISA, IP, WB
Unconjugated
2ml   85mg/ml   $1,140.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).