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GLP1R / GLP-1 Receptor

glucagon-like peptide 1 receptor

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003).

Gene Name: glucagon-like peptide 1 receptor
Family/Subfamily: GPCR , Glucagon
Synonyms: GLP1R, GLP-1-R, GLP-1 receptor, GLP-1R, GLP-I receptor, Glp1 receptor
Target Sequences: NM_002062 NP_002053.3 P43220

Publications (12)

1
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Diabetes. 2011 60:2397-406. (IHC-Fr; Mouse) [Full Text Article] [PubMed:21810596] [PMC:PMC3161330] Related Antibodies: LS-A1206, LS-A1205.
2
Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. The Journal of clinical investigation. 2012 122:388-402. (IHC; Mouse) [Full Text Article] [PubMed:22182839] [PMC:PMC3248276] Related Antibodies: LS-A1205.
3
GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE–/– Mice. Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ. Endocrinology. 2013 154:127-39. (WB; Mouse, Hamster) [Full Text Article] [PubMed:23183176] Related Antibodies: LS-A1205.
4
The Glucagon-Like Peptide-1 Receptor—or Not?. Pyke C, Knudsen LB. Endocrinology. 2013 154:8-Apr. (IHC-P; Human) [Full Text Article] [PubMed:23267050] Related Antibodies: LS-A1206, LS-A1205.
5
Equine glucagon-like peptide-1 receptor physiology. Kheder MH, Bailey SR, Dudley KJ, Sillence MN, de Laat MA. PeerJ. 2018 January;6:e4316. (Human) [Full Text Article] [PubMed:29404215] [PMC:PMC5793710]
6
Expression of the GLP-1 receptor in mouse, rat, and human pancreas. Tornehave D, Kristensen P, R[Character f8]mer J, Knudsen LB, Heller RS. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2013 Sep;56:841-51. [Full Text Article] [PubMed:18541709] [PMC:PMC2516959] Related Antibodies: LS-A1206.
7
Ex vivo imaging of pancreatic beta cells using a radiolabeled GLP-1 receptor agonist. Connolly BM, Vanko A, McQuade P, Guenther I, Meng X, Rubins D, Waterhouse R, Hargreaves R, Sur C, Hostetler E. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2004 Feb;14:79-87. [Full Text Article] [PubMed:21394533] Related Antibodies: LS-A1206.
8
Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury. Hirata Y, Kurobe H, Nishio C, Tanaka K, Fukuda D, Uematsu E, Nishimoto S, Soeki T, Harada N, Sakaue H, Kitagawa T, Shimabukuro M, Nakaya Y, Sata M. European journal of pharmacology. 2013 Jan;699:106-11. [Full Text Article] [PubMed:23220706] Related Antibodies: LS-A1206.
9
Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H. Diabetes. 2010 Apr;59:1030-7. [Full Text Article] [PubMed:20068138] [PMC:PMC2844811] Related Antibodies: LS-A1205.
10
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ. Diabetes. 2009 Apr;58:975-83. [Full Text Article] [PubMed:19151200] [PMC:PMC2661586] Related Antibodies: LS-A1205.
11
IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Mita T, Azuma K, Goto H, Jin WL, Arakawa M, Nomiyama T, Suzuki R, Kubota N, Tobe K, Kadowaki T, Fujitani Y, Hirose T, Kawamori R, Watada H. Biochemical and biophysical research communications. 2011 Dec;415:545-50. [Full Text Article] [PubMed:22074825] Related Antibodies: LS-A1205.
12
Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro. Baldassano S, Wang GD, Mul[Character e8] F, Wood JD. American journal of physiology. Gastrointestinal and liver physiology. 2012 Feb;302:G352-8. [Full Text Article] [PubMed:22075777] [PMC:PMC3287398] Related Antibodies: LS-A1205.
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GLP1R / GLP-1 Receptor (70)
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monoclonal mc (2)
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Yes (2)
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R antibody IHC staining of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Human
IF, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Mouse, Human
IF, IHC, IHC-Fr, IHC-P
APC Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R antibody IHC staining of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Biotin Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
FITC Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
APC Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (AP) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
AP Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
HRP Conjugated, Azide-free
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
PE Conjugated
100 µl/$650
GLP1R / GLP-1 Receptor Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Dog, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
GLP1R / GLP-1 Receptor Antibody - Immunohistochemistry: GLP1R Antibody - IHC analysis of GLP1R in mouse pancreas using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (aa250-350) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
GLP1R / GLP-1 Receptor Antibody - Immunohistochemistry: GLP1R Antibody - IHC analysis of GLP1R in mouse pancreas using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$406
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GLP1R / GLP-1 Receptor Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$501; 100 µg/$771
GLP1R / GLP-1 Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLP1R / GLP-1 Receptor Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLP1R / GLP-1 Receptor Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLP1R / GLP-1 Receptor Goat anti-Mouse Polyclonal (aa129-140) Antibody
Mouse
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
GLP1R / GLP-1 Receptor Antibody - Immunohistochemical analysis of GLP-1 Receptor staining in human pancreas formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$311
GLP1R / GLP-1 Receptor Antibody - GLP1R / GLP-1 Receptor antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing membrane staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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GLP1R / GLP-1 Receptor Goat anti-Human Polyclonal (aa211-222) Antibody
Rabbit, Mouse, Guinea pig, Rat, Pig, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$455
GLP1R / GLP-1 Receptor Antibody - Western blot of GLP-1R antibody
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (80-160 aa, Internal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
GLP1R / GLP-1 Receptor Antibody - Flow cytometric analysis of CHO-K1/GLP1/Ga15 stable cell expressing GLP1R and CHO negative control cell with GLP1R Antibody, mAb, Mouse (red and black respectively). The signal was developed with iFluor647 conjugated Goat Anti-Mouse IgG.
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GLP1R / GLP-1 Receptor Mouse Monoclonal (1F1E7) Antibody
ELISA, Flo, WB
Unconjugated
40 µg/$288
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$284; 100 µg/$348
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$284; 100 µg/$348
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$284; 100 µg/$348
GLP1R / GLP-1 Receptor Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLP1R / GLP-1 Receptor Rabbit anti-Mouse Polyclonal (aa101-150) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$414
GLP1R / GLP-1 Receptor Antibody - Immunohistochemical analysis of GLP-1 Receptor staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).