GLI3

GLI family zinc finger 3

Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

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Proteins (3)

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Recombinant (3)

Target

GLI3 (3)

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No (3)

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GST, N-terminus (1)

His-T7 (2)

Species

Human (2)

Mouse (1)

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E. coli (2)

Wheat Germ Extract (1)

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Human GLI3 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G58701

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GLI3 Protein (Recombinant His-T7) (aa111-343) - LS-G16037

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse GLI3 Protein (Recombinant His-T7) (aa303-561) - LS-G16040

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.5 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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