GLCNE / GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

GLCNE / GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

GLCNE / GNE (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human GLCNE / GNE Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61327

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GLCNE / GNE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89388

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.1 kDa

Price:

20 µg/$215

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Human GLCNE / GNE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89389

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$150

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Human GLCNE / GNE Protein (Recombinant GST) (Full Length) - LS-G31904

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

105.7 kDa

Price:

10 µg/$479; 25 µg/$670

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GLCNE / GNE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G131054

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

100 µg/$494

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Human GLCNE / GNE Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71275

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.1 kDa

Price:

20 µg/$1,107

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GLCNE / GNE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115941

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.1 kDa

Price:

100 µg/$710

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