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GLA / Alpha Galactosidase

galactosidase, alpha

GLA / Alpha Galactosidase encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene Name: galactosidase, alpha
Synonyms: GLA, Alpha-D-galactosidase A, Alpha-galactosidase A, Galactosidase, alpha, Melibiase, Alpha-gal A, GALA
Target Sequences: NM_000169 NP_000160.1 P06280

Publications (1)

1
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates. Xuling Zhu, Ling Yin, Matt Theisen, Jenny Zhuo, Summar Siddiqui, Becca Levy, Vladimir Presnyak, Andrea Frassetto, Jaclyn Milton, Timothy Salerno, Kerry E Benenato, Joe Milano, Andy Lynn, Staci Sabnis, Kristine Burke, Gilles Besin, Christine M Lukacs, Lin T Guey, Patrick F Finn, Paolo G V Martini. American journal of human genetics. 2019 Apr;104:625-637. [Full Text Article] [PubMed:30879639] [PMC:PMC6451694] Related Antibodies: LS-B11102.

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Antibodies (92)
Primary (92)
GLA / Alpha Galactosidase (92)
Human (75)
Mouse (20)
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rabbit (70)
mouse (21)
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IHCPlus (6)
IgG (46)
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monoclonal mc (20)
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Yes (1)
GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
GLA / Alpha Galactosidase Antibody - Anti-GLA / Alpha Galactosidase antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa150-429) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa147-371) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa81-429) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - GLA Antibody IHC of formalin-fixed and paraffin-embedded human Lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa83-112) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$371
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa1-80) Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa81-429) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$314; 200 µl/$359; 500 µl/$506; 1 ml/$580; 2 ml/$797; 5 ml/$1,295
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa81-429) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$342; 200 µl/$399; 500 µl/$587; 1 ml/$725; 2 ml/$962; 5 ml/$1,647
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.
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GLA / Alpha Galactosidase Rabbit anti-Mouse Polyclonal (aa29-258) Antibody
Mouse
WB
Unconjugated
100 µg/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
GLA / Alpha Galactosidase Antibody - Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa110-159) Antibody
Human
WB
Unconjugated
100 µl/$424
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
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GLA / Alpha Galactosidase Chicken anti-Human Polyclonal (aa55-64) Antibody
Human
ELISA, WB
Unconjugated
500 µg/$580; 100 µg/$729
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa81-429) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
GLA / Alpha Galactosidase Antibody - Immunofluorescent analysis of Alpha-galactosidase A staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa1-80) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GLA / Alpha Galactosidase Antibody - Western Blot; Sample: Recombinant GLa, Human.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa147-371) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
GLA / Alpha Galactosidase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
GLA / Alpha Galactosidase Mouse anti-Human Monoclonal (aa81-429) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
Select
GLA / Alpha Galactosidase Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa1-80) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308
GLA / Alpha Galactosidase Antibody - Western blot of recombinant GLA / Alpha Galactosidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal (aa1-80) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$317
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GLA / Alpha Galactosidase Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$271; 100 µl/$412
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).