GHRL / Ghrelin Preproprotein

Ghrelin/Obestatin Prepropeptide

GHRL / Ghrelin Preproprotein is the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

GHRL / Ghrelin Preproprotein (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human GHRL / Ghrelin Preproprotein (Recombinant His) - LS-G633

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human GHRL / Ghrelin Preproprotein (Recombinant GST) (Full Length) - LS-G33889

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.61 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GHRL / Ghrelin Preproprotein (Recombinant GST, N-terminus) (aa1-117) - LS-G64228

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human GHRL / Ghrelin Preproprotein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69419

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

10.4 kDa

Price:

20 µg/$1,107

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Human GHRL / Ghrelin Preproprotein (Recombinant GST, N-terminus) (aa24-117) - LS-G62530

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GHRL / Ghrelin Preproprotein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84594

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.93 kDa

Price:

20 µg/$150

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GHRL / Ghrelin Preproprotein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101432

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.93 kDa

Price:

100 µg/$494

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Human GHRL / Ghrelin Preproprotein (Recombinant His, N-Terminal) (Ser25-Lys117) - LS-G132988

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

12.0kDa

Price:

10 µg/$249; 50 µg/$307; 200 µg/$482; 100 µg/$385; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480

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