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Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe3+ iron to Fe2+ in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Gene Name: | biliverdin reductase B (flavin reductase (NADPH)) |
Synonyms: | BLVRB, Biliverdin-IX beta-reductase, BVR-B, Flavin reductase (NADPH), Green heme-binding protein, Flavin reductase, FR, SDR43U1, NADPH-dependent diaphorase, NADPH-flavin reductase, Biliverdin reductase B, BVRB, FLR, GHBP |
Target Sequences: | NM_000713 NP_000704.1 P30043 |
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