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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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GFRA1 / GFR Alpha
GDNF family receptor alpha 1
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa-1 recently. GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
| Gene Name: | GDNF family receptor alpha 1 |
| Family/Subfamily: | GDNF Receptor , Not assigned-Other |
| Synonyms: | GFRA1, GDNF receptor alpha-1, GDNFRA, GFR-ALPHA-1, GDNF family receptor alpha-1, GDNFR, GDNFR-alpha-1, RET ligand 1, RETL1, TRNR1, RET1L, GDNF family receptor alpha 1, GPI-linked anchor protein |
| Target Sequences: | NM_005264 NP_005255.1 P56159 |
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