GFI1B

growth factor independent 1B transcription repressor

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

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Antibodies (11)

Type

Primary (11)

Target

GFI1B (11)

Reactivity

Human (11)

Mouse (7)

Rat (6)

Bovine (3)

Dog (3)

Horse (3)

Monkey (1)

Application

IHC (7)

IHC-P (5)

WB (9)

ELISA (2)

Peptide-ELISA (1)

Host

rabbit (11)

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IHCPlus (1)

Isotype

IgG (8)

Clonality

monoclonal mc (1)

polyclonal pc (10)

Clone

D3G2 (1)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (8)

Epitope

N-Terminus (4)

C-Terminus (1)

Internal (1)

aa302-330 (1)

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No (11)

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IHC-plus™ GFI1B Antibody (Internal) LS-B13660

(4.0) Rating

Antibody:

GFI1B Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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GFI1B Antibody (N-Terminus) LS-C29813

Antibody:

GFI1B Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$424

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GFI1B Antibody (N-Terminus, HRP) LS-C425704

Antibody:

GFI1B Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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GFI1B Antibody (N-Terminus, Biotin) LS-C425700

Antibody:

GFI1B Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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GFI1B Antibody (N-Terminus, FITC) LS-C425701

Antibody:

GFI1B Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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GFI1B Antibody (aa302-330) LS-C203993

Antibody:

GFI1B Rabbit anti-Human Polyclonal (aa302-330) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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GFI1B Antibody (C-Terminus, clone D3G2) LS-C183867

Antibody:

GFI1B Rabbit anti-Human Monoclonal (C-Terminus) (D3G2) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$688

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GFI1B Antibody LS-C831315

Antibody:

GFI1B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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GFI1B Antibody LS-C830105

Antibody:

GFI1B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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GFI1B Antibody LS-C802313

Antibody:

GFI1B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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GFI1B Antibody LS-C411767

Antibody:

GFI1B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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