GFI1

growth factor independent 1 transcription repressor

Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.

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Proteins (7)

Type

Over-Expression Lysate (6)

Recombinant (1)

Target

GFI1 (7)

Publications

No (7)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (4)

Source

293T Cells (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124572

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

100 µg/$494

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GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124573

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

100 µg/$494

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GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116079

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

100 µg/$494

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Human GFI1 Protein (Recombinant GST, N-terminus) (aa1-91) - LS-G58682

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81732

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

20 µg/$150

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Human GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81733

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

20 µg/$150

Select

Human GFI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81734

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.1 kDa

Price:

20 µg/$150

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