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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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GDNF
glial cell derived neurotrophic factor
GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
| Gene Name: | glial cell derived neurotrophic factor |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | GDNF, HSCR3, HFB1-GDNF, ATF, HGDNF |
| Target Sequences: | NM_000514 NP_000505.1 P39905 |
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