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GDF15

growth differentiation factor 15

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

Gene Name: growth differentiation factor 15
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: GDF15, MIC1, MIC-1, NAG-1, NRG-1, NSAID-regulated gene 1 protein, PLAB, NSAID-activated gene 1 protein, Placental TGF-beta, PTGFB, GDF-15, PTGF-beta
Target Sequences: NM_004864 NP_004855.2 Q99988

Publications (1)

1
The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis. Boel De Paepe, Fien Verhamme, Jan L De Bleecker. Cytokine. 2020 March;127:154966. [Full Text Article] [PubMed:31901761] Related Antibodies: LS-B2413.

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Antibodies (101)
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GDF15 (101)
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GDF15 Antibody - Anti-GDF15 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ GDF15 Antibody (aa286-299) LS-B2413
(5.0) Rating
(1) Publication(s)
GDF15 Goat anti-Human Polyclonal (aa286-299) Antibody
Human
Flo, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
GDF15 Antibody - Anti-GDF15 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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IHC-plus™ GDF15 Antibody (C-Terminus, clone 6D12.H10.E4) LS-B8327
(4.0) Rating
GDF15 Rat anti-Human Monoclonal (C-Terminus) (6D12.H10.E4) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
GDF15 Antibody - Anti-GDF15 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IHC-plus™ GDF15 Antibody (aa51-79) LS-B8774
(4.0) Rating
GDF15 Rabbit anti-Human Polyclonal (aa51-79) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
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GDF15 Antibody (clone ME-6D10) LS-C89472
GDF15 Mouse anti-Human Monoclonal (ME-6D10) Antibody
Human
ELISA, Flo
Unconjugated
50 µg/$536; 100 µg/$836
GDF15 Antibody - Anti-NAG-1/GDF15 (C-terminal) Antibody - Western Blot. Western blot of affinity purified anti-NAG-1/GDF15 (C-terminal) antibody shows detection NAG-1 purified from CHO cells as a 14 kD band corresponding to monomer and a 28 kD band corresponding to dimerized NAG-1. Samples were electrophoresed on a 4-20% gradient gel under reducing conditions. Lane 1 shows NAG-1 detection. Lane 2 shows reactivity is blocked when this antibody is pre-incubated with the immunizing peptide prior to Western blotting. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GDF15 Antibody (Biotin) LS-C154298
GDF15 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
100 µg/$544
GDF15 Antibody - Western blot of recombinant GDF15. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GDF15 Antibody (aa193-296) LS-C294352
GDF15 Rabbit anti-Mouse Polyclonal (aa193-296) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
GDF15 Antibody - Anti-NAG-1 (H variant specific) Monoclonal Antibody - Western Blot. Western blot shows detection of recombinant NAG-1 protein present in Pichia pastoris whole cell lysates: lane 1 - yeast cell lysate expressing NAG-1 H variant with SUMO expression tag at 36 kD; lane 2 - yeast cell lysate expressing NAG-1 D variant with SUMO expression tag at 36 kD; lane 3 - yeast cell lysate expressing NAG-1 H variant; and lane 4 - yeast cell lysate expressing NAG-1 D variant. All lysates were run under reducing conditions. Primary antibody was used at a 1:1000 dilution in TBS containing 1% BSA and 0.2% Tween, and reacted overnight at 4°C. For detection, a 1:40000 dilution of peroxidase conjugated Gt-a-Mouse IgG secondary antibody (LS-C60680) was used in Blocking Buffer for Fluorescent Western Blot (MB-070) for 30 min at room temperature. Molecular weight estimation was made by comparison to prestained MW markers. Image was captured using the BioRad Versadoc 4000MP Imaging System.
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GDF15 Antibody (clone 7C12.B3.F2) LS-C154010
GDF15 Mouse anti-Human Monoclonal (7C12.B3.F2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$574
GDF15 Antibody - Anti-NAG-1/GDF15 (C-terminal) Antibody - Western Blot. Western blot of affinity purified anti-NAG-1/GDF15 (C-terminal) antibody shows detection NAG-1 purified from CHO cells as a 14 kD band corresponding to monomer and a 28 kD band corresponding to dimerized NAG-1. Samples were electrophoresed on a 4-20% gradient gel under reducing conditions. Lane 1 shows NAG-1 detection. Lane 2 shows reactivity is blocked when this antibody is pre-incubated with the immunizing peptide prior to Western blotting.
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GDF15 Antibody LS-C154238
GDF15 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
GDF15 Antibody - Anti-NAG-1 (D variant specific) Antibody - ELISA. In this sandwich ELISA, NAG-1 was captured from human serum using the following antibodies (see Related Products below): anti-NAG-1/GDF15 (C terminal specific), anti-NAG-1/GDF15 (N terminal specific (PAN)), anti-NAG-1/GDF15 (H-variant) and anti-NAG-1/GDF15 (D-variant) polyclonal antibodies. Micro titer plates were coated with capture antibody at 1 ug/mL. Control plates received PBS only (data not shown). After overnight incubation and blocking, independent experiments using 20 random normal human sera were performed. Neat normal sera were applied and incubated for 1 h at 37 °C. After washing, HRP conjugated anti-NAG-1/GDF15 (C terminal specific) antibody was added for detection at 100 ul per well at 1 ug/mL. Following further incubation for 1 hr at 37°C, the plates were washed and TMBE was added as an HRP substrate for 30 min. The reaction was stopped by 1 M H2SO4 and values were measured at 450nm.
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GDF15 Antibody LS-C154240
GDF15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
GDF15 Antibody - Anti-Mouse NAG-1/GDF15 Antibody - Western Blot. Western blot of affinity purified anti-mouse NAG-1/GDF15 antibody. The blot shows detection of recombinant MBP-NAG-1 fusion protein (60 kD) purified from E. coli (lane 1); yeast cell lysate expressing SUMO-mouse NAG-1 (42 kD) (lane 2), and R&D human NAG-1 monomer purified from CHO-K1 cells (14 kD) (lane 3). All lysates were run under reducing conditions. Primary antibody was used at a 1:1000 dilution in TBS containing 1% BSA and 0.2% Tween, and reacted overnight at 4C. Nag-1 was detected using a 1:40000 dilution of peroxidase conjugated Gt-a-Rabbit antibody (LS-C60865) in Blocking Buffer for Fluorescent Western Blot (MB-070) for 30 min at room temperature. Molecular weight estimation was made by comparison to prestained MW markers. Image was captured using the BioRad Versadoc 4000MP Imaging System. Other detection systems will yield similar results.
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GDF15 Antibody (C-Terminus) LS-C154321
GDF15 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$567
GDF15 Antibody - Western blot of GDF-15 antibody
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GDF15 Antibody (1-80 aa, Internal) LS-C383688
GDF15 Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GDF15 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using GDF15 Antibody at diluton of 1:50
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GDF15 Antibody LS-C211443
GDF15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
GDF15 Antibody - Western blot of Growth/differentiation factor 15 antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to rabbit IgG at 1:10000 dilution. Predicted band size: 34 kDa. Observed band size: 34 kDa. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GDF15 Antibody (Biotin) LS-C211446
GDF15 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
GDF15 Antibody - Immunohistochemistry of rabbit anti NAG1 antibody. Tissue: Human Colon at 20X in colon tissue at pH 6. Negative control of human colon tissue pH6 is shown in background.
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GDF15 Antibody LS-C745322
GDF15 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
25 µl/$304
GDF15 Antibody - Anti-NAG-1 (H variant specific) Antibody - ELISA. In this sandwich ELISA, NAG-1 was captured from human serum using the following antibodies (see Related Products below): anti-NAG-1/GDF15 (C terminal specific), anti-NAG-1/GDF15 (N terminal specific (PAN)), anti-NAG-1/GDF15 (H-variant) and anti-NAG-1/GDF15 (D-variant) polyclonal antibodies. Micro titer plates were coated with capture antibody at 1 ug/mL. Control plates received PBS only (data not shown). After overnight incubation and blocking, independent experiments using 20 random normal human sera were performed. Neat normal sera were applied and incubated for 1 h at 37 °C. After washing, HRP conjugated anti-NAG-1/GDF15 (C terminal specific) antibody was added for detection at 100 ul per well at 1 ug/mL. Following further incubation for 1 hr at 37°C, the plates were washed and TMBE was added as an HRP substrate for 30 min. The reaction was stopped by 1 M H2SO4 and values were measured at 450nm.
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GDF15 Antibody LS-C154239
GDF15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
GDF15 Antibody - Anti-NAG-1/GDF15 (N-terminal specific) Antibody - Western Blot. Western blot of affinity purified anti-NAG-1/GDF15 (N-terminal specific) antibody shows detection of a 14 kD band corresponding to recombinant human NAG-1 purified from CHO cells. Samples were electrophoresed on a 4-20% gradient gel under reducing conditions. Lane 1 shows NAG-1 detection. Lane 2 shows reactivity is greatly diminished when this antibody is preincubated with the immunizing peptide prior to Western blotting.
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GDF15 Antibody LS-C154241
GDF15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
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GDF15 Antibody (Biotin) LS-C154148
GDF15 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
100 µg/$552
GDF15 Antibody - Western blot using affinity purified anti-NAG-1/GDF15 (C-terminal) antibody shows detection NAG-1 purified from CHO cells as a 14 kDa band corresponding to monomer and a 28 kDa band corresponding to dimerized NAG-1. Samples were electro-phoresed on a 4-20% gradient gel under reducing conditions. Lane 1 shows NAG-1 detection. Lane 2 shows reactivity is blocked when this antibody is pre-incubated with the immunizing peptide prior to Western blotting.
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GDF15 Antibody (C-Terminus, HRP) LS-C154280
GDF15 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
100 µg/$544
GDF15 Antibody - Anti-NAG-1 (N-terminal specific) Monoclonal Antibody - Western Blot. Western blot shows detection of recombinant NAG-1 protein (arrow) present in Pichia pastoris whole cell lysates: lane 1 - yeast cell lysate expressing NAG-1 H variant with SUMO expression tag at 36 kD; lane 2 - yeast cell lysate expressing NAG-1 D variant with SUMO expression tag at 36 kD; lane 3 - yeast cell lysate expressing NAG-1 H variant; and lane 4 - yeast cell lysate expressing NAG-1 D variant. All lysates were run under reducing conditions. Primary antibody was used at a 1:1000 dilution in TBS containing 1% BSA and 0.2% Tween, and reacted overnight at 4°C. For detection, a 1:40000 dilution of peroxidase conjugated Gt-a-Mouse IgG secondary antibody (LS-C60680) was used in Blocking Buffer for Fluorescent Western Blot (MB-070) for 30 min at room temperature. Molecular weight estimation was made by comparison to prestained MW markers. Image was captured using the BioRad Versadoc 4000MP Imaging System.
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GDF15 Antibody (clone 23G10.E4.F8) LS-C154011
GDF15 Mouse anti-Human Monoclonal (23G10.E4.F8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$574
GDF15 Antibody - Western blot of lysate from HT-1080 cell line with GDF15 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.
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GDF15 Antibody (aa258-293) LS-C344398
GDF15 Rabbit anti-Human Polyclonal (aa258-293) Antibody
Human
WB
Unconjugated
400 µl/$393
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GDF15 Antibody (aa51-79) LS-C321597
GDF15 Rabbit anti-Human Polyclonal (aa51-79) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
GDF15 Antibody (aa51-79, Biotin) LS-C520256
GDF15 Rabbit anti-Human Polyclonal (aa51-79) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
GDF15 Antibody (aa51-79, APC) LS-C259490
GDF15 Rabbit anti-Human Polyclonal (aa51-79) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
GDF15 Antibody (aa51-79, PE) LS-C259493
GDF15 Rabbit anti-Human Polyclonal (aa51-79) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
GDF15 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PathPlus™ GDF15 Antibody LS-A11194
Fast Shipping
(5.0) Rating
GDF15 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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