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GCM2
glial cells missing homolog 2 (Drosophila)
GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
| Gene Name: | glial cells missing homolog 2 (Drosophila) |
| Synonyms: | GCM2, Glial cells missing 2, GCM motif protein 2, GCMB, HGCMb, Glide/gcm protein homolog, Glial cells missing homolog 2, Glial cells missing homolog b |
| Target Sequences: | NM_004752 NP_004743.1 O75603 |
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