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GAX / MEOX2

mesenchyme homeobox 2

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Name: mesenchyme homeobox 2
Synonyms: MEOX2, MOX2, Mesenchyme homeobox 2, GAX, Homeobox protein MOX-2
Target Sequences: NM_005924 NP_005915.2 P50222

Publications (1)

1
Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function. Tomislav Kokotovic, Ewelina M Lenartowicz, Michiel Langeslag, Cosmin I Ciotu, Christopher W Fell, Angelica Scaramuzza, Michael J M Fischer, Michaela Kress, Josef M Penninger, Vanja Nagy. The FEBS journal. 2022 June;289:3457-3476. [Full Text Article] [PubMed:35029322] [PMC:PMC9306780] Related Antibodies: LS-B5472.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
GAX / MEOX2 (6)
No (6)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
GAX / MEOX2 Protein
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E. coli
His, N-Terminal
33.6 kDa
50 µg/$419
GAX / MEOX2 Protein - 12.5% SDS-PAGE of human MEOX2 stained with Coomassie Blue
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Wheat Germ Extract
GST
59.07 kDa
2 µg/$439
GAX / MEOX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.4 kDa
20 µg/$150
GAX / MEOX2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GAX / MEOX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.4 kDa
100 µg/$494
GAX / MEOX2 Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).